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Use of insulin rather than oral antidiabetic agents for the treatment of type 2 diabetes and gestational diabetes mellitus (GDM) permits maintenance of blood glucose at concentrations as close to normal as possible.

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Compared to their effects in the heart, beta-blockers have relatively little vascular effect because β 2-adrenoceptors have only a small modulatory role on basal vascular tone.

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The goal of treatment is to lower blood pressure to levels that will prevent heart disease and other complications of hypertension.

Dissolution profiles of test and reference products were found to be comparable but the conditions were not specified.

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Sixty-one patients did not undergo randomization: 53 were already taking a beta-blocker at enrollment and underwent the planned vascular surgical procedure while continuing to take this medication, and 8 had extensive wall-motion abnormalities.

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Because of the very low dose of HCTZ employed, this may be less likely with bisoprolol fumarate and hydrochlorothiazide.

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Bisoprolol minimizes the side effects that might occur from administration of a nonspecific beta blocker where blockage of the other adrenoreceptors (β 2, β 3, α 1, α 2) occurs.

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The per-protocol-population excluded nine patients entirely from the analysis: four who never took the study medication (one randomized to bisoprolol-first and three to enalapril-first), one with unstable CHF, three with inadmissible prior therapy, and one who did not meet the inclusion criteria.

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However, coronary revascularization has not been shown to improve survival in patients with coronary artery disease and heart failure without angina, although regional ventricular function may improve.

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It seems unlikely that the risks of worsening asthma or COPD outweigh the potential benefits of beta blocker use, in these patients.

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Keep this medicine in the container it came in, tightly closed, and out of reach of children.

Limited data suggest bisoprolol fumarate is not dialyzable; similarly, there is no indication that hydrochlorothiazide is dialyzable.

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Single doses of cholestyramine and colestipol resins bind the hydrochlorothiazide and reduce its absorption in the gastrointestinal tract by up to 85% and 43%, respectively.

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In other cases, patients may have sustained left ventricular damage as a result of myocardial infarction, onset of dilated cardiomyopathy or some other progressive disease process compromising left ventricular systolic function but remain asymptomatic or very minimally symptomatic.

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